The Aqua x Barbie collab is to die for with pink tweed matching sets and heart-shaped hoops. As we await Gerwig’s cinematic presentation, here are all the Barbie collabs we’re shopping to live out our inner girly-girl dreams: 1. And while we have high hopes for the movie to help us relive every rose-colored childhood memory, we’re not about to rely on the virtual experience alone. Life in plastic really is fantastic.įrom modern to retro, all of Barbie’s eras are covered by the collabs, and fans have their pick of pinked-out merch. Taking over the fashion, home decor and gaming scene are Barbie x (fill in the blank) collections, and, as the OG influencer, Barbie is no doubt delighted. A marketer's dream with an unmistakable color palette and the most recognizable name in history, the trademark logo has been scrawled over everything from bath towels to park benches. #Barbiemovie collabs are popping up everywhere, and, so far, seem to be a massive hit. ![]() Sure to be the breakout hit of the summer, the Barbie movie’s press tour is in full swing and retailers are already cashing in. Things were good.Īlas, gone are the days of imaginative play and full-service snacks, and our favorite toy has gone Hollywood. ![]() Cruising down the imaginary Pacific Coast Highway in the pink convertible felt almost as good as the real thing, as we waited for mom to bring cookies and pink lemonade. Summers spent playing Barbies with a best friend were the best kind. ![]() Before there was TikTok, we had plastic human caricatures with impressive wardrobes and a dream car to engage imaginations. Images of Robbie sporting bubblegum-hued sets and matching stilettos is giving nostalgia and evoking warm childhood memories. The Barbie movie, directed by Greta Gerwig and starring two of Hollywood’s biggest names – Margot Robbie and Ryan Gosling – is coming soon to a theater near you. Big hair and blue eyeshadow lovers’ dreams are coming true this summer, and unless you’ve been living off the grid, you’ve likely heard a thing or two about it.
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![]() Push notifications to keep you in the knowįor everyone from small teams to large companies, Producteev by Jive is a better way to work. Integration with Box and Dropbox make it easy to upload and attach files Filters that allow you to sort and view your tasks in numerous ways Shortcuts that help you quickly create, schedule and assign tasks Group tasks that allow multiple people to collaborate Seamless integration between apps to keep your tasks synced 100% FREE for an unlimited number of users, projects and tasks Producteev is a workable alternative to solutions like Basecamp, though the space will surely be keeping a close eye on Dustin Moskovitz's Asana. With an intuitive and elegant interface, Producteev helps you and your team manage projects, tasks and email across your organization for free! Create to-do lists, assign tasks, set due dates and reminders, and get real-time updates on your Android. Today, Producteev is unveiling a slew of new apps, including a significantly upgraded web app, iPhone and Android mobile apps, and new Windows 7 and Mac desktop apps. This video is a Producteev project management tool tutorial in which Tim Levy tells you about the great features of this awesome project management tool. The World's Best Task Management App - Free For You And Your Team. Producteev users can easily capture and manage their tasks right from their desktop. "The task management service I've been longing for" - Techcrunch 1:56 Get Producteev 92K views8 years ago 1:31 Producteev by Jive 14K views9 years ago 1:11 Producteev - Free Task Management Application 22K views10 years ago 5:41 TechCrunch Disrupt 654. Producteev is a task management application for teams and individuals. "Much more than a multiple-project to-do list" - GigaOM “The task management service of your dreams" - VentureBeat Build a site and generate income from purchases, subscriptions, and courses. Host virtual town halls, onboard and train employees, collaborate efficiently. PRODUCTEEV BY JIVE HELPS TEAMS BE MORE PRODUCTIVE WITH A SIMPLE YET POWERFUL TASK MANAGEMENT APP Create and promote branded videos, host live events and webinars, and more. Enjoy millions of the latest Android apps, games, music, movies, TV, books, magazines & more. Which are subject to a 50% restocking fee. Undamaged items are subject to a 20% restocking fee, except for easels Smooth formula provides great results every time. Sets fast in 20-30 minutes without shrinking. This product is manufactured in United States. Purpose of use for Painting Supplies, wall-surface-repair-products. Online and in-store purchases, with some exceptions. This item is a DAP 10304 Plaster Wall Patch, White, 25 lb. You can return unopened, resalable merchandise within 30 days for both Weeks, and "special order" items can take four to six weeks. "warehouse only" and "out of stock" items usually ship within two Most orders of in-stock items ship within two business days, ArtPlaster is certified non-toxic and ACMI approved. Once dry, it can be painted and finished. WE ARE NOT RESPONSIBLE FOR DAMAGE TO YOUR BOX (ES) DURING SHIPPING. ![]() This strong, self-hardening clay is perfect for all levels of sculptors, as it allows for many clay sculpting techniques from hand building to throwing, and accepts a wide variety of finishes.ĪrtPlaster sets up in thirty minutes and is microwaveable or will air dry. Quantity Add to Cart DUE TO HIGH SHIPPING RATES AND RISK OF BOX BREAKAGE FOR ITEMS WEIGHING 50 LBS AND ABOVE, WE STRONGLY SUGGEST YOU PICK UP PLASTER IN ONE OF OUR STORES. Create craft projects such as wall plaques, candle bases, bookends, lamp bases, figurines, etc. casting, and hobby use, DAP Plaster of Paris features a smooth formula that provides great results every time. A premium quality casting plaster, superior to standard plaster of Paris, that makes perfect reproductions of any object within minutes and is an excellent medium for casting decorative figurines in molds. Pottery Plaster is harder than plaster of paris, but not as hard as Densite®. Getting the vaccine for your child and teen is safe and can stop the spread of the virus and protect your family from COVID-19. ![]() The COVID-19 virus is still spreading, and its course has not always been predictable. And even children who have no symptoms from COVID-19 illness can-and have-developed lasting symptoms weeks to months after they recover, known as Thousands of children also have needed care in the hospital. ![]() RememberĬOVID-19 illness was one of the top 10 causes of death for kids 5 to 11 years old this past year. Other less common side effects include: feeling like you might vomit feeling sick in your stomach lumps in your neck pain in your leg not sleeping well. We have years of research and monitoring on other vaccinations that show side effects almost always happen within six weeks of getting a vaccine. While further validation is required, our results suggest that monitoring digestive symptoms following COVID-19 vaccination can help detect rather severe complications that require medical intervention. COVID-19 infection is much more likely to cause myocarditis in children, especially children who develop multisystem inflammatory syndrome, than the vaccine.Īs for long-term side effects from the vaccine, the CDC says COVID-19 vaccines caused digestive symptoms and other complications that ranged from mild to severe. Having COVID-19 disease also can lead to this type of heart inflammation. Myocarditis, or inflammation of the heart muscle. When the vaccine was being studied, a small number of children had lymph node swelling. If you think your child might be having a severe allergic reaction after you leave the appointment, seek immediate medical care by calling 911. There are medicines to quickly treat allergic reactions. The good news is that the COVID-19 vaccines have similar side. That's why your child will need to wait for 15 to 30 minutes after they have a vaccination. Like with any vaccination, there is potential for side effects after you get your shot. It is rare, but some people have had a severeĪllergic reaction to the COVID-19 vaccine. But you can ask your pediatrician about ways to help your child feel better. These symptoms usually go away in a day or so on their own. Short-term side effects that your child may feel: It is important to note that children 5-11 years old had short-term side effects less often than older adolescents and adults. These are very similar to the ones that adults experience from the COVID-19 vaccine.Ĭlinical trials, some children and adolescents had no side effects and, like adults, more children and adolescents had short-term side effects after the second dose of the vaccine compared to after their first dose. There are some mild or moderate short-term side effects that your child may experience. It does not store any personal data.The COVID-19 vaccines that are approved for use in children and teens are safe. The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. The cookie is used to store the user consent for the cookies in the category "Performance". This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other. The cookies is used to store the user consent for the cookies in the category "Necessary". Injection site pain and swelling, rashes, headache, fatigue, body ache, fever, cough, cold, abdominal pain, nausea, and vomiting. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". The cookie is used to store the user consent for the cookies in the category "Analytics". Symptoms may include: fever or chills cough shortness of breath fatigue muscle or body aches headache new loss of taste or smell sore throat congestion or runny nose nausea or vomiting. These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. Division of Public Health, Surveillance and Response.You may report side effects to the FDA at 1-80. Call your doctor for medical advice about side effects. If you notice any other effects, check with your healthcare professional. Centre for Respiratory Diseases and Meningitis Other side effects not listed may also occur in some patients.Centre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses.Centre for Emerging Zoonotic and Parasitic Diseases. ![]() COVID-19 Vaccine Breakthrough Cases Frequently Asked Questions. ![]() Using actions to speed up video workflows Understanding still image concepts such as resolution and bit depth is honored to host this content in our library. This course was created and produced by Rich Harrington. The course also covers using the Photoshop editing tools and video timeline for advanced tasks, such as correcting lens distortion, color grading, and enhancing depth of field. He also works through a series of practical techniques, from designing and animating a logo to creating a gradient wipe for use in motion backgrounds. Author Rich Harrington describes core digital imaging concepts and shows how to perform basic image adjustments, such as correcting exposure and contrast. This course details Adobe Photoshop features of use to video editors. Venture into the Hidden World where dragons roam free under the watchful eye of their leader Toothless as, above ground, Hiccup struggles to assume leadership of his tribe. Featuring hundreds of pieces of original art and commentary from director Dean De Blois and the many talented artists and filmmakers who have created this masterpiece of storytelling and animation.Ī beautifully designed hardcover volume featuring exclusive commentary and never-before-seen art from the creation of the animated motion picture masterpiece!ĭon your winged Flight Suit, grab your Dragon Blade, hop on your obedient Night Fury, and get ready for the ride of a lifetime with your favorite dragons and Vikings in the latest installment in the How to Train Your Dragon trilogy! Fans will delight in the discovery of previously unknown dragons, the threat of a heartless villain, and the quest for sanctuary that propels the story to extraordinary new heights (and depths!). ![]() In this brilliantly illustrated, full-color book, Dark Horse Books and DreamWorks Animation join forces to celebrate the climatic third film showcasing more adventures of Toothless and Hiccup. ![]() Whether you like to drink your breakfast or you need a little sustenance after a workout, these keto smoothies are sure to give you a good boost. Every smoothie has three cups of spinach and freeze-dried whole fruits and vegetables, plus brazil nuts. If you’ve been missing smoothies that are high in sugar, you can now get your fix with Catalina Crunch Keto Smoothies, too! These low-carb smoothies are great to have on hand for a quick breakfast on the go and are available in three delicious flavors.Įach Catalina Crunch Smoothie is packed with antioxidants, vitamins, and minerals that your body needs. You really don’t need an excuse to get your spooning on with this tasty stuff.īut wait, there’s more Catalina Crunch goodness to enjoy!Ĭrunchy keto cereal isn’t the only yummy thing that Catalina Crunch has in store for us. Start your morning with a bowl of fruity low-carb cereal or gobble it up as a midday snack or post-dinner treat. It’s so good that Catalina Crunch enthusiasts have to hide it from themselves for fear of eating the whole bag in one sitting. It’s got all of the crunch and none of the sugar. ![]() ![]() It’s honestly just as delicious eaten by the handful!” – CollinĬatalina Crunch is a shameless sweet treat every low-carber needs in their life.īelieve it or not, this fruity keto cereal is just as delicious as it looks. “Oh how I love a good cereal crunch and this new fruity flavor is awesome! All the flavors are delicious, and I love how crunchy they stay even when swimming in a bowl of unsweetened almond milk. Either way, it’s fruity magic and we’re forever grateful to the chefs over in the Catalina Crunch kitchen for making keto breakfasts more exciting for us! □Ĭatalina Crunch Cereal is keto-friendly and has zero added sugar, is grain-free, gluten-free, 100% vegan, and non-GMO. We were already huge fans of this tasty low-carb cereal, but the new Catalina Crunch Fruity flavor is really something worth celebrating! Some say it tastes like fruity pebbles, while others say it tastes like fruit loops. That’s where Catalina Crunch Keto Cereal steps in to save the day (or at least the morning)! It’s loaded with carbs and sugar, and one bowl is enough to ruin your diet for the entire day. It’s no surprise that cereal isn’t something you can often enjoy on a ketogenic diet.
![]() To define the prevalence of KLF5 superenhancer amplification across cancers, we examined SNP array–based copy-number data targeting the ∼600 kb intergenic region between KLF5 and KLF12 on chromosome segment 13q22.1 across 10,844 samples from 33 cancer types included in The Cancer Genome Atlas (TCGA). ![]() In noncoding regions, somatic mutations are known to increase the activity of distal enhancers or super-enhancers to activate ESR1 and TAL1 expression ( 18, 19). In addition, somatic single-nucleotide variants (SNV) can activate oncogenic transcription factors for example, missense mutations in the degron domains of NFE2L2 stabilize the protein by preventing its binding to the E3 ubiquitin ligase KEAP1 ( 16, 17). For example, somatic structural variations such as copy-number amplifications increase gene dosage of MYC, MYCN, AR, MITF, and SOX2 and upregulate their expression ( 1–6) chromosomal translocations can place regulatory elements such as enhancers or super-enhancers adjacent to oncogenes and activate their expression, as observed with MYC, MYB, and ERG ( 7–12) whereas amplification of noncoding superenhancers is known to activate MYC ( 13–15). Genomic alterations during tumorigenesis can lead to the activation of oncogenic transcription factors, resulting in aberrant gene regulation throughout the genome. This article is highlighted in the In This Issue feature, p. Significance: Our observations, together with previous studies that identified oncogenic properties of KLF5, establish the importance of KLF5 activation in human cancers, delineate the varied genomic mechanisms underlying this occurrence, and nominate KLF5 as a putative target for therapeutic intervention in cancer. Utilizing data from CRISPR/Cas9 gene knockout screening, we reveal that cancer cells with KLF5 overexpression are dependent on KLF5 for their proliferation, suggesting KLF5 as a putative therapeutic target. Here, we show that these alterations activate KLF5 by three distinct mechanisms: (i) Focal amplification of superenhancers activates KLF5 expression in squamous cell carcinomas (ii) Missense mutations disrupt KLF5–FBXW7 interactions to increase KLF5 protein stability in colorectal cancer (iii) Cancer type–specific hotspot mutations within a zinc-finger DNA binding domain of KLF5 change its DNA binding specificity and reshape cellular transcription. We recently reported that the KLF5 gene is also subject to other types of somatic coding and noncoding genomic alterations in diverse cancer types. Krüppel-like factor 5 gene ( KLF5) has been shown to promote cancer cell proliferation and tumorigenesis and to be genomically amplified in cancer cells. The Krüppel-like family of transcription factors plays critical roles in human development and is associated with cancer pathogenesis. ![]() But harmful effects manifest when a person’s hourly dosage of ionizing radiation exceeds certain thresholds. Strictly speaking, everyone on Earth is continuously exposed to low levels of ambient radiation. Cleaning Up America's Worst Nuclear Waste DumpĪdmittedly, that might have increased risks of congestion along the main route, and imposed limits on the defensive perimeter Russian forces could set up.īut maybe that would have spared some soldiers from radiation sickness, which can be deadly in the short and long term.Russian forces theoretically could have transited through Chernobyl with minimal radiation exposure as well by avoiding the Red Forest and other high-risk areas. In peacetime, tourists who visit the exclusion zone are not-by virtue of following regulations-overly exposed to health hazards. Yet Russian commanders deployed their regular soldiers into heavily irradiated areas near Chernobyl, either without regard for their safety, or out of ignorance of the risks. During the Cold War, armies expected their troops to keep on fighting on battlefields irradiated by tactical nuclear weapons, and equipped and trained their forces accordingly. Like any major military power, Russia has long maintained a corps of specialized CBRN or NBC troops trained to help mitigate radiation hazards, as well as products of other types of WMDs. It’s shocking that Russia’s military disregarded the well-known radiation hazards persisting around Chernobyl. Looting did result in loss of customized monitoring software used to monitor radiation safety levels. 4 was not compromised, despite a scare related to a loss of electrical power in mid-March. Prior to the war, Russia’s intention to advance via this road could be seen by the building of a pontoon bridge to ford a river on the Belarussian side of the border across from Chernobyl.īy the afternoon of the war’s first day, columns of the 36th Combined Arms Army had seized Chernobyl, accepting the surrender of the local National Guard detachment and taking roughly 210 civilian staff, as well as the guardsmen, hostage.įortunately, the integrity of the sarcophagus around Reactor No. Situated amidst the Pripyet marshes on Ukraine’s border with Belarus, the P56 highway running through Chernobyl happened to offer one of just a handful of convenient invasion routes to the Ukrainian capital of Kyiv. During Russia’s occupation, Ukrainian sources claimed Russian soldiers were pulled from garrison duty for treatment at radiation research center in Gomel, Belarus-a claim later supported by doctors in Belarus affiliated with the opposition. ![]() The U.K.’s Telegraph alleged in April 2022 that a Russian soldier died from radiation exposure at Chernobyl. The identity of the source is unclear, but these are not the first such claims of radiation sickness amongst Russian troops in that area.
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